Schisandra chinensis is a deciduous woody vine native to northern China and eastern Russia, commonly known as Wu Wei Zi in Traditional Chinese Medicine, meaning “five-flavor fruit” due to its unique combination of sweet, sour, salty, bitter, and pungent tastes. It has been utilized for over 2,000 years in traditional Chinese, Korean, and Russian medicine primarily for its adaptogenic, hepatoprotective, and tonic properties. Ancient texts describe its use for treating liver disorders, respiratory ailments, fatigue, insomnia, and to enhance vitality and longevity.
In contemporary research, Schisandra chinensis has garnered significant interest for its bioactive lignans, such as schisandrin A, B, and C, and gomisin A, which demonstrate potent antioxidant, anti-inflammatory, neuroprotective, and metabolic regulatory effects. Studies indicate potential benefits in improving cognitive function, reducing oxidative stress, supporting liver health, and alleviating fatigue. As an adaptogen, it helps the body resist stressors. Today, it is available as a dietary supplement, often promoted for stress management, liver support, and overall wellness.
Can improve:
- diabetes [ r ]
- fatigue [ a ]
- inflammatory cytokines (↓TNF-α, IL-1β, IL-6) [ q ]
- liver injury [ b | c | q ]
- cognitive function [ d | e ]
- menopausal symptoms [ f ]
- muscle endurance [ q ]
- muscle strength [ g | q ]
- non-alcoholic fatty liver disease [ h ]
- obesity [ r ]
- oxidative stress markers (↓MDA; ↑SOD, GSH) [ q ]
Can prevent:
Reduces:
- oxidative stress markers (ROS, MDA) [ k ]
- inflammatory cytokines (TNF-α, IL-6) [ l ]
- blood glucose levels [ m ]
- body weight [ r ]
- fatigue indicators [ n ]
- insulin resistance [ o ]
Increases:
Side-effects:
- heartburn [ f ]
- upset stomach [ f | q ]
- decreased appetite [ f ]
- acid reflux [ n ]
- nausea [ n ]
- vomiting [ n ]
Safety profile (A):
Dosage
| Low | 500 mg/d |
| Moderate | 1,000 mg/d |
| Max | 1,500 g/day |